After the business is genuinely established and trading, with capital committed and contracts signed. Applying before the enterprise exists in fact is the common cause of refusal.
Build the business first; the application describes what exists
The sequence that works runs against instinct. Incorporate, secure premises or a documented workspace, obtain the necessary registrations and insurance, buy the equipment, sign the client agreements, spend the money and begin trading; then apply, describing a real operating enterprise. Applying at the point of incorporation asks a reviewer to accept a plan, and the classification specifically excludes speculative undertakings.
This creates genuine commercial exposure, because the money is spent before the outcome is known, and that exposure is inherent to the route rather than a fixable defect. Reduce it where you can by keeping the Canadian work relationship intact until a decision, by choosing short initial lease terms that are still real commitments, and by staging hiring. Then allow for consular appointment availability, which varies, and remember that each renewal re-examines whether the business still qualifies.